陈浩东 博士

副教授


1999 – 2003     北京大学生命科学学院 学士

2003 – 2008     北京大学生命科学学院 博士

2004 – 2006    北京生命科学研究所 访问学生

2006 – 2008     耶鲁大学分子细胞与发育生物学系 交换学生

2008 – 2010     北京大学球盟会qmh网页版登录/化学学院 博士后

2010 – 2020     北京大学生命科学学院 副研究员

2020 – 2023     球盟会qmh网页版登录生命科学学院 助理教授

2023 – 至今     球盟会qmh网页版登录生命科学学院 副教授

2020 – 至今     清华-北大生命科学联合中心 研究员

 

●  研究兴趣、领域:


作为地球上持续存在的核心物理环境因子,重力在调控植物的生长方向与形态建成等方面发挥至关重要的作用。本实验室综合运用小立碗藓、拟南芥、水稻等模式植物,探索植物中重力感受与信号传递的机制,具体研究:(1)植物感受重力的机制;(2)植物中向重力性方向决定的机制;(3)植物向性的改良。这些研究将为地球上植物的性状改良乃至太空环境下的植物培育提供知识基础,有力推动农业创新与生态建设。

 

●  代表性论文:


1. Chen, J., Yu, R., Li, N., Deng, Z., Zhang, X., Zhao, Y., Qu, C., Yuan, Y., Pan, Z., Zhou, Y., Li, K., Wang, J., Chen, Z., Wang, X., Wang, X., He, S.-N., Dong, J., Deng, X.W., and Chen, H.* (2023). Amyloplast sedimentation repolarizes LAZYs to achieve gravity sensing in plants. Cell 186, 4788-4802.

2. Li, Y., Deng, Z., Kamisugi, Y., Chen, Z., Wang, J., Han, X., Wei, Y., He, H., Terzaghi, W., Cove, D.J., Cuming, A.C., Chen, H.* (2021). A minus-end directed kinesin motor directs gravitropism in Physcomitrella patens. Nat Commun 12, 4470.

3. Wang, X., Yu, R., Wang, J., Lin, Z., Deng, Z., He, H., Fan, L., Deng, X.W., and Chen, H.*(2020). The asymmetric expression of SAUR genes mediated by ARF7/19 promotes the gravitropism and phototropism of plant hypocotyls. Cell Rep, 31, 107529.

4. Yang, P., Wen, Q., Yu, R., Han, X., Deng, X.W.*, and Chen, H.* (2020) .Light modulates the gravitropic responses through organ-specific PIFs and HY5 regulation of LAZY4 expression in Arabidopsis. Proc Natl Acad Sci U S A117, 18840-18848.

5. Dong, J., Sun, N., Yang, J., Deng, Z., Lan, J., Qin, G., He, H., Deng, X.W., Irish V.F.,  Chen, H.* and Wei, N.* (2019) .TCP4 and PIF3 antagonistically regulate organ-specific light induction of SAUR16/50 to modulate cotyledon opening during de-etiolation in Arabidopsis.   Plant Cell 31, 1155-1170.

6. Dong, J., Ni, W., Yu, R., Deng, X.W.,Chen, H.* and Wei, N. (2017). Light-dependent degradation of PIF3 by SCFEBF1/2 promotes a photomorphogenic response in Arabidopsis. Curr Biol 27, 2420-2430.  

7. Sun, N., Wang, J., Gao, Z., Dong, J., He, H., Terzaghi, W., Wei, N., Deng, X.W.,* and Chen, H.*(2016). Arabidopsis SAURs are critical for differential light regulation of the development of various organs. Proc Natl Acad Sci U S A 113, 6071-6076.

8. Li, K., Yu, R., Fan, L.M., Wei, N., Chen, H.* and Deng, X.W.* (2016). DELLA-mediated PIF degradation contributes to coordination of light and gibberellin signalling in Arabidopsis. Nat Commun7, 11868. 

9. Li, K., Gao, Z., He, H., Terzaghi, W., Fan, L.M., Deng, X.W.,* and  Chen, H.* (2015). Arabidopsis DET1 represses photomorphogenesis in part by negatively regulating DELLA protein abundance in darkness. Mol Plant8, 622-630.

10. Dong, J., Tang, D., Gao, Z., Yu, R., Li, K., He, H., Terzaghi, W., Deng, X.W., and Chen, H.* (2014). Arabidopsis DE-ETIOLATED1 represses photomorphogenesis by positively regulating phytochrome-interacting factors in the dark. Plant Cell 26, 3630-3645.

11. Chen, H.# Xie, W., # He, H., # Yu, H., # Chen, W., Li, J., Yu, R., Yao, Y., Zhang, W., He, Y., Tang, X., Zhou, F., Deng, X.W., and Zhang, Q. (2014). A high-density SNP genotyping array for rice biology and molecular breeding. Mol Plant 7, 541-553.

12. Chen, H.* He, H., Zhou, F., Yu, H., and Deng, X.W.* (2013). Development of genomics-based genotyping platforms and their applications in rice breeding. Curr Opin Plant Biol 16, 247-254.

13. Chen, H., # Huang, X.,# Gusmaroli, G., Terzaghi, W., Lau, O.S., Yanagawa, Y., Zhang, Y., Li, J., Lee, J.H., Zhu, D., and Deng, X.W. (2010). Arabidopsis CULLIN4-Damaged DNA Binding Protein 1 interacts with CONSTITUTIVELY PHOTOMORPHOGENIC1-SUPPRESSOR OF PHYA complexes to regulate photomorphogenesis and flowering time. Plant Cell 22, 108-123.

14. Chen, H. Shen, Y., Tang, X., Yu, L., Wang, J., Guo, L., Zhang, Y., Zhang, H., Feng, S., Strickland, E., Zheng, N., and Deng, X.W. (2006). Arabidopsis CULLIN4 forms an E3 ubiquitin ligase with RBX1 and the CDD complex in mediating light control of development. Plant Cell 18, 1991-2004.

(# First author, * Corresponding author)

 

 

●  荣誉、奖励及参加学术团体的情况:

中国植物学会植物生理及分子生物学专业委员会委员 (2024-2028)

北京植物学会理事 (2023-2028)

国家自然科学基金委优秀青年科学基金(2020)

Member of the international Molecular Moss Science Society (2016至今)

北京大学绿叶生物医药杰出青年学者奖(2016)

北京大学优秀博士后(2010)

北京大学优秀博士毕业生(2008)


●  联系方式:


邮箱: chenhaodong@tsinghua.edu.cn

电话:010-62790868(办公室);010-62793033(实验室)

地址:球盟会qmh网页版登录生物技术馆3-112室(办公室);3-105室,3-110室(实验室)