张颖 博士

助理教授


2008-2012 南京大学,学士

2012-2017 浙江大学,博士

2017-2023 麻省理工学院,博士后

2023-至今 球盟会qmh网页版登录生命科学学院,助理教授

2023-至今 清华-IDG/麦戈文脑科学研究院&清华-北大生命联合中心,研究员

 

●  研究兴趣、领域:


丘脑坐落在大脑的正中,是一个被熟知的重要的感觉传导中转站。其实,除了信息转导功能外,丘脑还参与了部分“非转导”功能。研究表明,丘脑的正常神经元活动与学习记忆相关联,其局部损伤可以导致睡眠失调和情绪紊乱。在帕金森以及阿尔兹海默症患者脑内均检测出丘脑结构或功能异常。然而,关于丘脑的“非转导”功能及其在脑疾病中的作用,研究甚少。我们结合基因编辑,电生理,在体钙成像等技术,从基因到环路等多个层面探索丘脑的“非转导”功能及其在各种神经精神疾病中的作用,以求找到相应的丘脑靶向的致病治疗策略。

实验室网站链接:https://www.yingzhanglab.com/


●  代表性论文:


(*Co-first authors #Co-corresponding authors)

1. Tome DF*#, Zhang Y*#, Aida T, Mosto O, Lu YF, Chen M, Sadeh S, Roy DS#, Clopath C#, “Dynamic and selective engrams emerge with memory consolidation”, Nature Neuroscience, 2024.

2. Zhang Y*#, Roy DS*#, Zhu Y, Chen Y, Aida T, Hou Y, Shen C, Lea NE, Schroeder ME, Skaggs KM, Sullivan HA, Fischer KB, Callaway EM, Wickersham IR, Dai J, Li XM, Lu Z, Feng G#, “Targeting thalamic circuits rescues motor and mood deficits in PD mice”, Nature, 2022.

3. Roy DS*#, Zhang Y*#, Aida T, Shen C, Skaggs KM, Hou Y, Fleishman M, Mosto O, Weninger A, Feng G#, “Anterior thalamic circuits crucial for working memory”, PNAS, 2022.

4. Roy DS*, Park YG*, Kim ME*, Zhang Y*, Ogawa SK*, DiNapoli N, Gu X, Cho JH, Choi H, Kamensky L, Martin J, Mosto O, Aida T, Chung K, Tonegawa S, “Brain-wide mapping reveals that engrams for a single memory are distributed across multiple brain regions”, Nature Communications, 2022.

5. Roy DS*#, Zhang Y*, Aida T, Choi S, Chen Q, Hou Y, Lea NE, Skaggs KM, Quay JC, Liew M, Maisano H, Le V, Jones C, Xu J, Kong D, Sullivan HA, Saunders A, McCarroll SA, Wickersham IR, Feng G#, “Anterior thalamic dysfunction underlies cognitive deficits in a subset of neuropsychiatric disease models”, Neuron, 2021.

6. Zhang Y*, Zhu Y*, Cao SX*, Sun P, Yang JM, Xia YF, Xie SZ, Yu XD, Fu JY, Shen CJ, He HY, Pan HQ, Chen XJ, Wang H, Li XM, “MeCP2 in cholinergic interneurons of nucleus accumbens regulates fear learning”, Elife, 2020.

7. Cao SX*, Zhang Y*, Hu XY, Hong B, Sun P, He HY, Geng HY, Bao AM, Duan SM, Yang JM, Gao TM, Lian H, Li XM, “ErbB4 deletion in noradrenergic neurons in the locus coeruleus induces mania-like behavior via elevated catecholamines”, Elife, 2018.

8. Zhang Y*, Cao SX*, Sun P, He HY, Yang CH, Chen XJ, Shen CJ, Wang XD, Chen Z, Berg D, Duan SM, Li XM, “Loss of MeCP2 in cholinergic neurons causes part of RTT-like phenotypes via a7 receptor in hippocampus”, Cell Research, 2016.


●  联系方式:


电话:010-62771320(实验室)

邮箱:y_zhang@mail.tsinghua.edu.cn

通讯地址:球盟会qmh网页版登录生物医学馆B403