吝易 博士

副教授


2005-2009年   江南大学,学士

2009-2014年   马凯特大学,博士

2014-2020年   得克萨斯大学西南医学中心,博士后 

2020-2023年   球盟会qmh网页版登录生命科学学院,助理教授

2024年-至今  球盟会qmh网页版登录生命科学学院,副教授

2020年-至今   清华-IDG/麦戈文脑科学研究院、清华-北大生命科学联合中心,研究员

 

●  研究兴趣、领域:


球盟会qmh网页版登录吝易实验室主要致力于生物大分子相分离及神经退行性疾病相关研究。

细胞中特定的生物大分子通过相分离作用在胞内局部聚集,形成无膜包被的新型细胞器。无膜细胞器在细胞内实现精细的时空区隔,并具有特异的空间分布和更灵活的调节性能,与众多重要生理功能相关。然而,蛋白质的异常相分离导致不溶性蛋白质聚集,最终引发细胞病理变化和一系列蛋白质聚集性疾病,如神经退行性疾病。实验室的研究旨在解析生物大分子的相分离性质和分子机制,并结合疾病模型,探究蛋白质相分离与细胞功能,尤其是神经系统相关功能之间的关系。

我们希望利用生化、细胞及神经生物学等手段,建立体内外研究模型,系统性地回答以下几个关键科学问题:

1、解析驱动生物大分子相分离发生的分子机制。

2、探索神经系统中特异的无膜细胞器及理解其重要生理意义。

3、如何通过人工干预的手段调控病理状态下的异常相变,从而治疗神经退行性疾病。


●  代表性论文:


1. Liang Yang#, Jiali Lyu#, Xi Li#, Gaigai Guo#, Xueya Zhou, Taoyu Chen, Yi Lin*, Tingting Li*. Phase separation as a possible mechanism for dosage sensitivity. Genome Biology. 2024 Jan 15; 25(1):17.

2. Ke Ruan*, Yi Lin*, Peiguo Yang*, Wen Zhou*. Condensation matters. Nature Chemical Biology. 2023 Oct; 19(10):1180-1182. (Meeting Reports)

3. Songhao Zhang#, Gaofeng Pei#, Boya Li#, Pilong Li*, Yi Lin*. Abnormal phase separation of biomacromolecules in human diseases. Acta biochimica et biophysica Sinica. 2023 Jul 21; 55(7), 1133-1152. (Review)

4. Yanrong Zhuang#, Zhiyuan Li#, Shiyue Xiong#, Chujie Sun#, Boya Li, Shuangcheng Alivia Wu, Jiali Lyu, Xiang Shi, Liang Yang, Yutong Chen, Zhangbin Bao, Xi Li, Chuhanwen Sun, Yuling Chen, Haiteng Deng, Tingting Li, Qingfeng Wu, Ling Qi, Yue Huang, Xuerui Yang*, Yi Lin*. Circadian clocks are modulated by compartmentalized oscillating translation. Cell. 2023 Jul 20; 186(15):3245-3260.e23.

5. Shuangcheng Alivia Wu, Chenchen Shen, Xiaoqiong Wei, Xiawei Zhang, Siwen Wang, Xinxin Chen, Mauricio Torres, You Lu, Liangguang Leo Lin, Huilun Helen Wang, Allen H Hunter, Deyu Fang, Shengyi Sun, Magdalena I Ivanova, Yi Lin*, Ling Qi*. The mechanisms to dispose of misfolded proteins in the endoplasmic reticulum of adipocytes. Nat Commun. 2023 May 30;14(1):3132.

6. Hongyao Sun#, Yutong Chen#, Kun Yan, Yanqiu Shao, Qiangfeng C Zhang, Yi Lin*, Qiaoran Xi*. Recruitment of TRIM33 to cell-context specific PML nuclear bodies regulates nodal signaling in mESCs. The Embo Journal. 2023 Feb 1; 42(3): e112058.

7. Yifei Gao#, Xi Li#, Pilong Li*, Yi Lin*. A brief guideline for studies of phase-separated biomolecular condensates. Nature Chemical Biology. 2022 Nov 18; 18(12):1307-1318. (Review)

8. Xiang Shi#, Yanrong Zhuang#, Zhenhua Chen, Mingrui Xu, Junqi Kuang, Xue-Lian Sun, Lisen Gao, Xia Kuang, Huairen Zhang, Wei Li, Samuel Zheng Hao Wong, Chuanyu Liu, Longqi Liu, Danhua Jiang, Duanqing Pei, Yi Lin*, QingFeng Wu*. Hierarchical deployment of Tbx3 dictates the identity of hypothalamic KNDy neurons to control puberty onset. Science Advances. 2022 Nov 16; 8(46): eabq2987.

9. Yi Lin*, Xiaofeng Fang*. Phase separation in RNA biology. Journal of Genetics and Genomics. 2021 Oct 20;48(10):872-880. (Review)

10. Yi Lin, Xiaoming Zhou, Masato Kato, Daifei Liu, Sina Ghaemmaghami, Benjamin P Tu, Steven L McKnight*. Redox-mediated regulation of an evolutionarily conserved cross-beta structure formed by the TDP43 LC domain. Proc. Natl. Acad. Sci. USA. 2020 Nov 17;117(46):28727-28734.

11. Dylan T Murray#, Masato Kato#, Yi Lin, Kent R Thurber, Ivan Hung, Steven L McKnight*, Robert Tycko*. Structure of FUS Protein Fibrils and Its Relevance to Self-Assembly and Phase Separation of  Low-Complexity Domains. Cell. 2017 Oct 19;171(3):615-627.e16.

12. Yi Lin#, Eiichiro Mori#, Masato Kato#, Siheng Xiang#, Leeju Wu, Ilmin Kwon*, Steven L McKnight*. Toxic PR Poly-Dipeptides Encoded by the C9orf72 Repeat Expansion Target LC Domain Polymers. Cell. 2016 Oct 20; 167(3):789-802.e12.


●  荣誉、奖励及参加学术团体的情况:


Oliver Smith Academic Achievement Award (2013)
Marquette University Fellowship (2012-2014)
Richard W. Jobling Award (2012-2013)

●  联系方式:


电话:010-62798206

邮箱:linyi@mail.tsinghua.edu.cn

通讯地址:北京市海淀区双清路30号球盟会qmh网页版登录生物医学馆B205

实验室网站:http://linyi-lab.life.tsinghua.edu.cn/home/