钟毅 博士

教授


教育经历:
1978-1982年,球盟会qmh网页版登录工程物理系               学士
1982-1985年,球盟会qmh网页版登录生物科学与技术系     硕士
1985-1991年,美国爱荷华大学生物科学系     博士

工作经历:
1992-1998年,美国冷泉港实验室                   助理教授
1998-2004年,美国冷泉港实验室                   副教授
2004-2013年,美国冷泉港实验室                   教授
2001-2013年,球盟会qmh网页版登录生命科学学院            兼职教授
2013年至今,球盟会qmh网页版登录生命科学学院               教授


●  研究兴趣、领域:



综合利用果蝇和小鼠等模式生物的研究优势,探究学习、记忆和遗忘的生物学机制。在此基础上,一方面致力于推进人类记忆相关疾病病理机制的研究和潜在治疗药物的开发,另一方面致力于理解生物智能的深层机理并为人工智能的研究提供启发。

●  代表性论文:


Lei, B., Lv, L., Hu, S., Tang, Y., and Zhong, Y*. (2022). Social experiences switch states of memory engrams through regulating hippocampal Rac1 activity. Proc Natl Acad Sci U S A 119, e2116844119.

Lei, B., Kang, B., Lin, W., Chen, H., Hao, Y., Ma, J., Shi, S., and Zhong, Y*. (2022). Adult newborn granule cells confer emotional state-dependent adaptability in memory retrieval. Science advances 8, eabn2136.

Lv, L., Liu, Y., Xie, J., Wu, Y., Zhao, J., Li, Q., and Zhong, Y*. (2019). Interplay between alpha2-chimaerin and Rac1 activity determines dynamic maintenance of long-term memory. Nature communications 10, 5313.

Zhang, X., Li, Q., Wang, L., Liu, Z.J., and Zhong, Y*. (2018). Active Protection: Learning-Activated Raf/MAPK Activity Protects Labile Memory from Rac1-Independent Forgetting. Neuron 98, 142-155 e144.

Dong, T., He, J., Wang, S., Wang, L., Cheng, Y., and Zhong, Y*. (2016). Inability to activate Rac1-dependent forgetting contributes to behavioral inflexibility in mutants of multiple autism-risk genes. Proc Natl Acad Sci U S A 113, 7644-7649.

Wang, L., Chiang, H.C., Wu, W., Liang, B., Xie, Z., Yao, X., Ma, W., Du, S., and Zhong, Y*. (2012). Epidermal growth factor receptor is a preferred target for treating amyloid-beta-induced memory loss. Proc Natl Acad Sci U S A 109, 16743-16748.

Shuai, Y.C., Lu, B.Y., Hu, Y., Wang, L.Z., Sun, K., and Zhong, Y*. (2010). Forgetting Is Regulated through Rac Activity in Drosophila. Cell 140, 579-589.

Pagani, M.R., Oishi, K., Gelb, B.D., and Zhong, Y*. (2009). The Phosphatase SHP2 Regulates the Spacing Effect for Long-Term Memory Induction. Cell 139, 186-198.


●  荣誉、奖励及参加学术团体的情况:


1994- 1997年,“Pew”生物医学优秀学者奖

 

●  联系方式:


电话:010-62772273
E-mail:zhongyithu@tsinghua.edu.cn