刘念 博士

副教授


2010年/中国科学技术大学/学士

2015年/芝加哥大学/博士

2015-2019年/斯坦福大学/博士后

2019年-2022年/球盟会qmh网页版登录生命科学学院-生命科学联合中心/助理教授

2022年-至今/球盟会qmh网页版登录生命科学学院-生命科学联合中心/副教授


●  研究兴趣、领域:


转座子是可以移动(或转座)的DNA,存在于几乎所有的生命体中,属于基因组中的‘暗物质’。转座子在人体内大量富集,占据大约一半的人体DNA,并且仍然具有转座活性。人体转座子的活性与胚胎发育、神经发育以及上百种疾病密切相关,但是其相关机理和功能至今不是非常清楚。我们利用分子、细胞、生化、高通量测序和生统等手段主攻转座子活性是如何被调控的机理,及其在发育和疾病中的具体功能。


●  代表性论文:


1. Li X*, Bie L*, Wang Y*, Hong Y*, Zhou Z, Fan Y, Yan X, Tao Y, Huang C, Zhang Y, Sun X, Li J, Zhang J, Chang Z, Xi Q, Meng A, Shen X, Xie W, Liu N#. LINE-1 transcription activates long-range gene expression. Nature Genetics, accepted.

2. Hong Y*, Bie L*, Zhang T*, Yan X, Jin G, Chen Z, Wang Y, Li X, Pei G, Zhang Y, Hong Y, Gong L, Li P, Xie W, Zhu Y, Shen X, Liu N#. SAFB restricts contact domain boundaries associated with L1 chimeric transcription. Molecular Cell (2024) https://doi.org/10.1016/j.molcel.2024.03.021

3. Liu, N.*, Lee, C.*, Swigut, T., Grow, E., Gu, B., Bassik, M.#, and Wysocka, J#. Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators. Nature 553, 228-232 (2018).

4. Liu, N., Dai, Q., Zheng, G., He, C., Parisien, M.#, Pan, T#. N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions. Nature 518, 560-564 (2015).

5. Liu, N.*, Pan, T.* N6-methyladenosine-coded RNA Epigenetics. Nat. Struct. Mol. Biol. 23, 98-102 (2016).

6. Liu, N.*, Zhou, K.*, Parisien, M., Dai, Q., Diatchenko, L., and Pan, T#. N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein. Nucleic Acids Res. 45 (10), 6051-6063 (2017).

7. Liu, N., Parisien, M., Dai, Q., Zheng, G., He, C., and Pan, T#. Probing N6-methyl-adenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA. RNA 19, 1848-1856 (2013).

 

●  荣誉、奖励及参加学术团体的情况:


Benyuan Fund – Young Investigator Exploration Fellowship in Life Sciences (2024)

Bayer Investigator Award (2020)

Jane Coffin Child Foundation Fellowship (2016-2019)

RNA Society / Scaringe Graduate Student Award (2016)

Award for Outstanding Self-financed Students Abroad (2016)

Aldrich Alfred R. Bader Award for Student Innovation (2015)


●  联系方式:


实验室网页:http://liulab.life.tsinghua.edu.cn/

邮箱:liunian88@tsinghua.edu.cn

通讯地址:北京市球盟会qmh网页版登录生命科学学院,刘念实验室 100084