鲁志 博士

副教授


2017-至今 球盟会qmh网页版登录 生命科学学院 副教授,博士生导师

2011-2016 球盟会qmh网页版登录 生命科学学院 助理教授,博士生导师

2008-2011 耶鲁大学 生物信息学 博士后

2003-2008 罗切斯特大学 生物物理学 博士

1998-2003 中国科学技术大学 生命科学学院 学士


●  研究兴趣、领域:



我们致力于发展生物信息学技术,并探索其在癌症、自身免疫等复杂疾病精准诊疗上的具体实践。我们利用机器学习等人工智能技术,结合非编码RNA (ncRNA)为核心的多组学数据,来研究遗传信息是如何被编码在结构化的DNA和RNA分子之中,以及它们是如何在一个生命体系中相互作用、彼此调控。

“上工治未病”,我们的一个重要使命,是帮助人们更早期的发现癌症。我们相信,这种使命感以及为此付出的实践和努力,将帮助我们理解和治疗人类疾病,并最终认识和提高我们自己。

实验室围绕着非编码RNA (ncRNA)主要有两个研究方向: 1.生物信息驱动的精准医疗;2.AI驱动的 RNA靶标和药物设计



●  代表性论文:


· Mingyang Li1, Tianxiu Zhou1, Mingfei Han1, Hongke Wang, Pengfei Bao, Yuhuan Tao, Xiaoqing Chen, Guansheng Wu, Tianyou Liu, Xiaojuan Wang, Qian Lu*, Yunping Zhu*, Zhi John Lu* (2024) cfOmics: a cell-free multi-Omics database for diseases. Nucleic Acids Research 52(D1):D607-D621 (1contributed equally, *co-corresponding authors)

· Yuhuan Tao1, Shaozhen Xing1, Shuai Zuo1, Pengfei Bao, Yunfan Jin, Yu Li, Yingchao Wu, Shanwen Chen, Xiaojuan Wang, Yumin Zhu, Ying Feng, Xiaohua Zhang, Xianbo Wang, Qiaoran Xi, Qian Lu*, Pengyuan Wang*, Zhi John Lu* (2023) Cell-free multi-omics analysis reveals potential biomarkers in gastrointestinal cancer patients’ blood. Cell Reports Medicine 4(11):101281 (1contributed equally, *co-corresponding authors)

· Shanwen Chen1, Yunfan Jin, Siqi Wang1, Shaozhen Xing1, …, Zhenjiang Zech Xu*, Zhi John Lu*, Pengyuan Wang* (2022) Cancer Type Classification Using Plasma Cell Free RNAs Derived from Human and Microbes. eLife 11:e75181 (1contributed equally, *co-corresponding authors)

· Weihao Zhao1, Shang Zhang1, …, Yucheng T Yang*, Zhi John Lu* (2022) POSTAR3: an updated platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins. Nucleic Acids Research 50(D1):D287-D294

· Shuaishuai Teng1, Yang Eric Li1, …, Zhi John Lu* and Dong Wang* (2020) Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer. Cell Research 30(1):34-49

· Zhiyu Xu1, Long Hu1, …, Dong Wang* & Zhi John Lu* (2018) Ribosome elongating footprints denoised by wavelet transform comprehensively characterize dynamic cellular translation events. Nucleic Acids Research 46 (18), e109-e109

· Jiapei Yuan1, Jingrui Li1, …, Yijun Qi* & Zhi John Lu* (2018) Stress-responsive regulation of long noncoding RNAs’ polyadenylation in Oryza sativa. The Plant Journal (1contributed equally) 93:5, 814-827

· ENCODE Project Consortium#. (2012) An Integrated Encyclopedia of DNA Elements in the Human Genome. Nature 489, 57–74. (#Lu Z was a member of ENCODE Consortium) [Cover Story] (cited  ~20,000)

· Gerstein MB 1*, Lu ZJ1, Van Nostrand EL1, Cheng C1, Arshinoff BI1, et al. (2010) Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science 330(6012): 1775-1787 (20 co-first authors, *15 co-corresponding authors, ~150 authors in total) [Cover Story]


●  荣誉、奖励及参加学术团体的情况:


“霍英东”青年基金获得者, “新世纪人才计划”获得者


●  联系方式:


球盟会qmh网页版登录 生命科学学院,生物信息学“教育部重点实验室”, 北京,中国,100084
Tel. /FAX: +86-10-62789217
E-mail: lulab1 AT tsinghua.edu.cn
实验室主页: https://www.ncRNAlab.org | http://lulab.life.tsinghua.edu.cn